Why is adherence to the prescribed INH regimen crucial?

Adherence to the prescribed isoniazid (INH) regimen is crucial primarily because it significantly reduces the risk of developing drug-resistant tuberculosis (TB). When patients do not follow the prescribed treatment plan, whether by missing doses or stopping medication prematurely, it allows the TB bacteria to survive and potentially adapt, leading to drug resistance. This makes the infection more difficult to treat and can result in the spread of resistant strains of TB, which pose a serious public health threat.

Consistent adherence to the regimen ensures that the bacteria are thoroughly eradicated and minimizes the chances of them mutating. This is particularly important in populations where TB is prevalent, as well as for individuals who may have compromised immune systems. Managing TB effectively requires a full course of medication to ensure all bacteria are eliminated, preventing the emergence of resistance.

While minimizing drug interactions and avoiding side effects are important aspects of medication management, and weight gain might be a concern for some patients, these factors are secondary to the primary goal of preventing drug resistance. Thus, maintaining a strict adherence to the INH regimen is essential to control and eradicate TB effectively.