Which symptom is indicative of hepatotoxicity that may occur with INH?

The symptom indicative of hepatotoxicity associated with isoniazid (INH) is jaundice. Jaundice occurs when there is an accumulation of bilirubin in the blood, which can result from liver dysfunction. Since INH is metabolized in the liver, it has the potential to cause liver damage, leading to an increase in bilirubin levels. Jaundice is characterized by the yellowing of the skin and the eyes, which is a direct result of impaired liver function.

Recognizing jaundice as a symptom of liver toxicity is crucial, especially for patients on INH, as it necessitates prompt medical evaluation and intervention. This is essential to prevent serious complications. The other symptoms listed, such as shortness of breath, severe headache, and rash, while they may arise in various medical conditions or side effects from different drugs, are not specific indicators of hepatotoxicity linked to INH. Therefore, jaundice stands out as a significant warning sign of potential liver damage.