Which population is most at risk for INH-induced hepatotoxicity?

The population most at risk for INH-induced hepatotoxicity is older adults and those with pre-existing liver disease. This risk is primarily due to the metabolic processes of isoniazid (INH) that are influenced by the liver's function. In older adults, the liver may not metabolize drugs as effectively as it does in younger adults, leading to a higher likelihood of drug accumulation and subsequent toxicity.

Additionally, individuals with pre-existing liver conditions already have compromised liver function, which can be exacerbated by the administration of INH. The liver is crucial for drug metabolism, and any pre-existing dysfunction can lead to increased vulnerability to drug-induced liver injury. Factors such as age-related physiological changes and existing liver disease significantly increase the likelihood of hepatotoxic effects when these individuals are exposed to INH.

In contrast, children under 12 tend to metabolize drugs at rates comparable to adults, and while pregnant women must take caution with medications, they do not show a heightened risk for INH-induced hepatotoxicity specifically. Athletes, while they may present unique health factors, are not considered a high-risk group for this particular side effect of INH. Therefore, the combination of age and liver health makes older adults and those with existing liver disease the