Which organ systems are particularly at risk from overlapping toxicities when using INH with other medications?

The liver and nervous system are particularly at risk from overlapping toxicities when using isoniazid (INH) with other medications. INH is known for its potential hepatotoxic effects, which can lead to liver damage or dysfunction, especially when combined with other drugs that also stress the liver or have hepatotoxic potential.

Furthermore, the nervous system can be affected due to INH’s ability to deplete pyridoxine (vitamin B6), which is essential for proper neurological function. This depletion can lead to symptoms such as peripheral neuropathy, especially when INH is taken alongside medications that have neurotoxic effects.

Therefore, the correct choice highlights the specific organ systems—liver and nervous system—that are more likely to suffer from harmful interactions when INH is prescribed with other medications, underlining the importance of monitoring these areas closely in clinical practice.