What symptom might indicate the need to discontinue INH therapy?

Jaundice or abdominal pain is a significant symptom that may indicate the need to discontinue INH (Isoniazid) therapy. This is primarily because these symptoms can be indicative of hepatotoxicity, a serious side effect associated with INH use.

Isoniazid can affect the liver, leading to liver inflammation or damage. Jaundice, which is a yellowing of the skin and eyes, occurs when there is an accumulation of bilirubin in the body, often due to liver dysfunction. Abdominal pain, particularly in the right upper quadrant, may also suggest liver issues. If patients on INH experience these symptoms, it is crucial to evaluate liver function tests and consider stopping the medication to prevent further liver damage.

Monitoring for hepatic effects is essential in patients undergoing treatment with INH, especially in those with pre-existing liver conditions or risk factors for liver disease. Understanding these potential side effects allows for timely interventions to ensure patient safety.