What should patients taking INH be monitored for regularly?

Patients taking isoniazid (INH) should be monitored regularly for liver function tests because INH is known to potentially cause hepatotoxicity. The liver is responsible for metabolizing the drug, and elevated levels of liver enzymes can indicate liver damage or non-function. This is particularly important because liver damage can occur silently without significant symptoms, especially in individuals who may be at higher risk, such as those with pre-existing liver conditions, alcohol use, or when taking other medications that affect the liver.

Regular monitoring of liver function tests, which includes measurements of enzymes like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), allows healthcare providers to detect any adverse effects early and adjust treatment accordingly, ensuring the safety of the patient while they are on INH therapy. Keeping track of these values helps prevent serious complications associated with liver injury.