What is the relationship between INH and drug-resistant tuberculosis?

The relationship between isoniazid (INH) and drug-resistant tuberculosis (TB) is crucial in understanding TB treatment and management. Proper adherence to the prescribed treatment regimen is essential because it ensures that the infection is effectively managed and minimizes the chance of developing drug-resistant strains of the bacteria.

When patients do not adhere to the treatment plan—either by missing doses or not completing the entire course of medication—there is an increased risk that the bacteria will not be completely eradicated. This incomplete treatment allows the bacteria to adapt and survive even in the presence of the drug, leading to resistance. Therefore, ensuring that patients follow their treatment protocol without interruption is a key factor in preventing the development of drug resistance. Adherence helps maintain the therapeutic concentration of the drug in the body, which is necessary to effectively kill the bacteria and prevent them from mutating.

The other choices do not accurately capture the critical impact of proper adherence on drug resistance. While factors like misdiagnosis and treatment interruption can contribute to resistance, the primary focus is largely on how adherence to treatment directly influences the likelihood of developing drug-resistant TB.