What is one strategy to minimize the risk of peripheral neuropathy with INH?

Co-administration of pyridoxine (vitamin B6) is an effective strategy to minimize the risk of peripheral neuropathy when using isoniazid (INH). This is because INH can interfere with the metabolism of vitamin B6, a critical nutrient for nerve health and function. The drug can deplete the body's levels of pyridoxine, potentially leading to neuropathic symptoms characterized by numbness, tingling, or pain in the extremities. By supplementing with pyridoxine, you can help restore adequate levels of this vitamin, thereby reducing the likelihood of developing peripheral neuropathy associated with INH treatment.

Increasing dietary fat intake, reducing the dose of INH, or administering vitamin C supplements do not address the need for vitamin B6 in counteracting the neurological side effects that can result from INH. These strategies may not be effective in preventing or managing the specific risk of peripheral neuropathy, making the co-administration of pyridoxine the most appropriate and targeted approach.