What is a potential consequence of non-adherence to INH therapy?

Non-adherence to isoniazid (INH) therapy can significantly impact the efficacy of treatment for tuberculosis (TB). One of the main risks associated with failing to properly follow an INH regimen is the increased likelihood of developing drug-resistant strains of TB. When patients do not take their medication as prescribed or stop treatment prematurely, the bacteria may not be fully eradicated. This incomplete treatment can lead to the remaining bacteria evolving and becoming resistant to the drug.

This drug resistance complicates future treatment plans and can lead to more severe health issues, necessitating the use of more toxic and less effective medications, or even resulting in a longer duration of infectiousness. As a result, public health becomes compromised because drug-resistant TB can spread, making it harder to control and treat TB outbreaks. Therefore, adherence to INH therapy is critical in preventing the development of drug resistance and ensuring a successful treatment outcome.