What is a common reason for patient noncompliance with INH therapy?

One of the most common reasons for patient noncompliance with isoniazid (INH) therapy is the presence of side effects such as nausea. When patients experience discomfort or adverse effects from a medication, it can significantly impact their willingness and ability to continue adhering to the treatment regimen. Nausea, in particular, can deter individuals from taking their medication as prescribed, leading them to skip doses or discontinue therapy altogether. This is particularly critical in the context of INH, which is essential for the treatment of tuberculosis.

While factors such as a complex dosing schedule, the cost of medication, and a lack of understanding about the condition can contribute to noncompliance, the psychological and physical impact of side effects tends to have a more immediate and powerful effect on a patient's ability to maintain adherence. If patients are feeling unwell, they may prioritize their comfort over the perceived benefits of treatment.