What guideline should patients follow concerning alcohol while on INH?

When patients are on isoniazid (INH), the guideline regarding alcohol consumption is to completely avoid it. This recommendation stems from the potential for alcohol to exacerbate the risk of hepatotoxicity, a significant side effect associated with INH. Both INH and alcohol are metabolized in the liver, and the combined use can lead to increased strain on the liver, elevating the risk of liver damage and impairing the drug’s effectiveness.

Additionally, alcohol can interfere with the metabolism of INH, leading to unpredictable blood levels and potentially reducing its efficacy in treating tuberculosis. This heightened risk of liver injury is particularly concerning in patients with pre-existing liver conditions or those who consume alcohol excessively, making complete abstinence from alcohol the safest guideline while on INH treatment.

By adhering to this guideline, patients can better safeguard their liver health and ensure the treatment remains as effective as possible.