What can be an early sign of INH-related liver toxicity?

Nausea and fatigue can be early signs of INH (isoniazid)-related liver toxicity because these symptoms often manifest when the liver is undergoing stress or damage. INH is known for its hepatotoxic potential, particularly in certain populations or when used in conjunction with other medications that impact liver function. The liver plays a crucial role in metabolizing drugs and toxins, and when it is compromised, patients may experience non-specific symptoms such as nausea and fatigue. These symptoms may indicate that the liver is not functioning properly and can serve as an early warning sign for healthcare professionals to monitor liver function more closely, potentially leading to the adjustment or discontinuation of INH therapy if necessary.

In contrast, the other symptoms such as headache, dizziness, dry skin, rash, or shortness of breath, while they can occur for various reasons, are less specific to liver function and more likely to indicate other issues, making them less reliable as early indicators of liver toxicity related to INH.