What are the first-line drugs typically used alongside INH for TB treatment?

The first-line drugs typically used alongside isoniazid (INH) for the treatment of tuberculosis (TB) are rifampicin, pyrazinamide, and ethambutol. This combination forms the backbone of standard TB treatment regimens.

Rifampicin is known for its effectiveness in rapidly killing Mycobacterium tuberculosis, the bacterium that causes TB, and it also has the advantage of reducing the duration of treatment when used in combination with INH. Pyrazinamide works by targeting the latent bacteria that INH and rifampicin may not fully eliminate, while ethambutol serves to prevent the development of drug resistance during treatment. Together, these drugs enhance the overall efficacy of the treatment, minimize the risk of developing resistant strains, and contribute to the successful eradication of the disease.

The other drug combinations mentioned in the choices do not typically form part of the first-line treatment for TB. Therefore, the combination of rifampicin, pyrazinamide, and ethambutol aligns with the recommended guidelines for TB therapy.