Can INH be used during pregnancy?

Isoniazid (INH) can be used during pregnancy, but it requires careful consideration due to the potential risks and benefits involved. The decision to use INH is often made when the benefits of treating active tuberculosis or preventing latent tuberculosis infection outweigh the potential risks to the mother and fetus.

There is evidence suggesting that untreated tuberculosis poses a significant risk to both maternal and fetal health, including the possibility of maternal mortality and adverse outcomes like low birth weight or preterm birth. Therefore, INH therapy may be considered essential in certain circumstances despite potential risks.

The careful assessment includes evaluating the mother's health, the prevalence of tuberculosis in the community, and considering alternative treatments or monitoring strategies. This nuanced approach underscores the importance of individualizing treatment plans during pregnancy, rather than applying a blanket rule against the medication.